Head coach Lionel Scaloni included the Atlanta United playmaker in his 28-man roster - alongside heavyweights Lionel Messi (PSG), Angel Di Maria (Juventus) and Julian Alvarez (Manchester City), among others - ahead of this month's preparation matches against Honduras (Sept. 23) and Jamaica (Sept. 27).
Argentina will also take on the United Arab Emirates in a final warm-up a week before making their Group C debut against Saudi Arabia on November 22.
For Almada, this call-up offers him a chance to debut with the adult squad after appearing with the U23 (3), U20 (7) and Olympic (2) sides.
Atlanta' record-setting signing, who joined earlier this year from Velez Sarsfield for a reported $16 million, has six goals and 11 assists to his name in his first MLS season, scoring the game winner in Wednesday's 1-0 victory at Orlando City SC.
The 21-year-old follows in the footsteps of Gonzalo "Pity" Martinez as the second Five Stripes Player to earn a call-up with Argentina.
Almada and Atlanta continue their late-season Audi 2022 MLS Cup Playoffs push on Saturday (3:30 pm ET | UniMás, TUDN, Twitter) against the Philadelphia Union.