USL carryover signing Forrest Lasso got the goal on the second header following a corner kick in the 59th minute.
The contest was the first of the season for the Rapids, who will relocate their preseason operations to Southern California next week. Meanwhile, Cincy had previously played to a 1-1 draw against the Montreal Impact on Wednesday.
FC Cincinnati (First Half): Przemysław Tytoń, Blake Smith, Nick Hagglund, Kendall Waston © (Hassan Ndam 30’), Mathieu Deplagne, Alvas Powell, Victor Ulloa, Leonardo Bertone, Fatai Alashe, Fanendo Adi, Emmanuel Ledesma
FC Cincinnati (Second Half): Przemysław Tytoń (Jimmy Hague 75’), Roland Lamah, Forrest Lasso, Justin Hoyte, Hassan Ndam, Logan Gdula, Eric Alexander (Tommy McCabe 75’), Corben Bone, Nazmi Albadawi, Darren Mattocks, Rashawn Dally (Frankie Amaya 80’)
Colorado Rapids (First Half): Tim Howard, Dillon Serna, Tommy Smith, Axel Sjöberg, Sebastian Anderson, Kellyn Acosta, Benny Feilhaber (Cole Bassett 32’), Jack Price, Nicolás Mezquida, Andre Shinyashiki, Diego Rubio
Colorado Rapids (Second Half): Andre Rawls, Dillon Serna, Danny Wilson, Sam Raben, Marcello Borges, Shkëlzen Gashi, Cole Bassett, Jordan Schweitzer, Johan Blomberg, Matt Hundley, Niki Jackson