It starts June 3 at Levi's Stadium in Santa Clara, California against Colombia. Then it's Costa Rica at Soldier Field in Chicago on June 7 and Group A closes against Paraguay on June 11 in Philadelphia (check out the full tournament schedule).
The US have a rich history with two of the three nations: They have faced Colombia twice in Copa America and at the 1994 World Cup, while Costa Rica is the USA's longtime foe in the CONCACAF region with the two teams facing off most recently in an October 2015 friendly.
Here's the complete US national team history against their Copa America Centenario foes:
The USA have not fared well against Colombia over the years, winning just three of 17 all-time matches. As mentioned above, one of those wins did come at the 1994 World Cup when they defeated Los Cafeteros 2-1 at the Rose Bowl. The two teams most recently squared off in October 2014 in London, England when Colombia defeated the US 2-1.
Colombia have had a rough go of it since their run to the quarterfinals of the 2014 World Cup. They finished third in their group at the 2015 Copa America and were defeated by Argentina in the quarterfinals. More recently, they've started poorly in World Cup qualifying, collecting just four points in their first four games.
The USA and Costa Rica have a long history, having faced each other a total of 33 times. Costa Rica hold a slight edge, 14-13-6, after defeating the US in a friendly last October at Red Bull Arena. They split their 2014 World Cup qualifying games, somewhat controversially, with each team winning their home match.
Costa Rica followed up their magical 2014 World Cup quarterfinal run with another heated 2015 Gold Cup quarterfinal elimination at the hands of Mexico when Andres Guardado scored a 124th-minute winner following a controversial penalty. The Ticos have gotten off to a solid start in 2018 World Cup qualifying, winning both of their games so far.
USA have less of a history with Paraguay, with the two nations facing off just six times. They have split the six matches, each team winning two. The most recent match came in March 2011 when Paraguay defeated the US 1-0 in a friendly in Nashville, Tennessee.
But watch out for Paraguay: They made an outstanding run to the 2015 Copa America semifinals, defeating Brazil in the quarterfinals after a penalty kick shootout. They've gotten off to a decent start in 2018 World Cup qualifying, earning two wins in their first four matches. However, those two wins came against the continents' minnows in Venezuela and Bolivia.