NOTE: This report is compiled on an ongoing basis by MLSsoccer.com editors based on club game notes, news reports, and original reporting. The league does not have an official player availability report.
- OUT: Ozzie Alonso (ACL)
- OUT: Dylan Castanheira (Achilles)
- OUT: Brad Guzan (Achilles)
- OUT: Miles Robinson (Achilles)
- OUT: Emerson Hyndman (quad)
- QUESTIONABLE: Dom Dwyer (hamstring)
Austin FC
- OUT: Freddy Kleemann (left knee)
- OUT: Zan Kolmanic (right knee)
- OUT: Vinicius Mello (left foot surgery)
- OUT: Adam Armour (left knee surgery)
- OUT: Guzman Corujo (right knee surgery)
- OUT: Gastón Giménez (right thigh)
- OUT: Fabian Herbers (right hip)
- OUT: Wyatt Omsberg (left foot)
- OUT: Andre Reynolds II (right knee)
- OUT: Jairo Torres (left lower leg)
- QUESTIONABLE: Gabriel Slonina (head)
- OUT: Kenneth Vermeer (torn pectoral muscle)
- OUT: Beckham Sunderland (concussion protocol)
Colorado Rapids
- OUT: Braian Galván (right knee)
- OUT: Aboubacar Keita (torn ACL right knee)
- OUT: Oliver Larraz (right leg)
- OUT: Dantouma Toure (right knee)
- OUT: Jackson Travis (core)
- QUESTIONABLE: Jack Price (hamstring)
- QUESTIONABLE: Jonathan Mensah (left thigh)
FC Dallas
- OUT: Bernard Kamungo (right ankle)
D.C. United
- OUT: Adrien Perez (foot)
- OUT: Brad Smith (knee)
- OUT: Brendan Hines-Ike (foot)
- OUT: Rafael Romo (knee)
- OUT: Andy Najar (thigh)
- OUT: Victor Palsson (thigh)
- QUESTIONABLE: Russell Canouse (head)
Houston Dynamo FC
- OUT: Daniel Steres (right arm)
- OUT: Xavier Valdez (head)
- QUESTIONABLE: Hector Herrera (right leg)
- QUESTIONABLE: None
- OUT: Jorge Villafaña (left knee)
- OUT: Jonathan Perez (knee)
Inter Miami CF
- OUT: Ian Fray (knee)
- OUT: Robbie Robinson (hamstring)
- QUESTIONABLE: Leo Campana (hamstring)
- QUESTIONABLE: Coretin Jean (knee)
- QUESTIONABLE: Alejandro Pozuelo (groin)
Minnesota United FC
- OUT: Bakaye Dibassy (thigh)
- OUT: Hassani Dotson (knee)
- OUT: Jacori Hayes (lower leg)
- OUT: Patrick Weah (knee)
CF Montréal
- OUT: Tomas Giraldo (foot)
Nashville SC
- QUESTIONABLE: None
- OUT: Jacob Jackson (leg)
- OUT: Ismael Tajouri-Shradi (leg)
- OUT: Maciel (left Achilles)
- QUESTIONABLE: DeJuan Jones (upper leg)
- QUESTIONABLE: Matt Polster (lower leg)
New York City FC
- QUESTIONABLE: Alfredo Morales (lower body)
- QUESTIONABLE: Tayvon Gray (lower body)
New York Red Bulls
- OUT: Cam Harper (quad)
- OUT: Zach Ryan (shoulder)
- OUT: Cristian Casseres Jr. (leg)
- QUESTIONABLE: Caden Clark (back)
Orlando City SC
- OUT: Joey DeZart (right knee)
- OUT: Alexandre Pato (right knee)
- OUT: Robin Jansson (right lower leg)
Philadelphia Union
- QUESTIONABLE: Alejandro Bedoya (hip flexor strain)
Portland Timbers
- OUT: George Fochive (right adductor)
- OUT: Felipe Mora (left knee)
Real Salt Lake
- OUT: Bobby Wood (abductor)
- QUESTIONABLE: Damir Kreilach (back)
- QUESTIONABLE: Aaron Herrera (calf)
- OUT: Gilbert Fuentes (personal)
- OUT: Ousseni Bouda (left foot)
- OUT: Siad Haji (right calf)
- QUESTIONABLE: Will Richmond (nose)
Seattle Sounders FC
- OUT: João Paulo (right ACL tear)
- OUT: Obed Vargas (lower back stress fracture)
- OUT: Andrew Thomas (lower back stress fracture)
- QUESTIONABLE: Raul Ruidiaz (right ankle sprain)
Sporting Kansas City
- OUT: Tim Melia (hamstring)
- OUT: Ozzie Cisneros (hamstring)
- OUT: Gadi Kinda (knee surgery)
- OUT: Alan Pulido (knee surgery)
Toronto FC
- OUT: Domenico Criscito (lowerbody)
- OUT: Lorenzo Insigne (lower body)
- OUT: Jonathan Osorio (upper body)
- OUT: Kosi Thompson (lower body)
- QUESTIONABLE: Federico Bernardeschi (lower body)
Vancouver Whitecaps FC
- OUT: Déiber Caicedo (right knee, meniscus surgery)
- OUT: Cristián Gutiérrez (left adductor tighrness)
