NOTE: This report is compiled on an ongoing basis by MLSsoccer.com editors based on club game notes, news reports, and original reporting. The league does not have an official player availability report.
- OUT: Machop Chol (hamstring)
Austin FC
- OUT: Žan Kolmanič (right ACL)
- QUESTIONABLE: Maxi Urruti (left knee)
- OUT: Vinicius Mello (right lower leg)
- OUT: Ben Bender (left knee)
- OUT: Chris Mueller (right upper leg)
- OUT: Nick Hagglund (hamstring)
- OUT: London Aghedo (leg)
Colorado Rapids
- OUT: Alex Gersbach (adductor tendon surgery)
- OUT: Danny Leyva (international duty)
- OUT: Sam Nicholson (lower body)
- OUT: Diego Rubio (international duty)
- OUT: Jack Price (Achilles)
- OUT: William Yarbrough (knee surgery)
- OUT: Max (removed from team activities)
- QUESTIONABLE: Marco Ilic (illness)
- OUT: Will Sands (knee)
FC Dallas
- OUT: Geovane Jesus (right knee)
- OUT: Tarik Scott (season-ending knee injury)
- OUT: Alan Velasco (knee)
- OUT: Nolan Norris (rest)
- QUESTIONABLE: Jesus Ferreira (undisclosed)
- QUESTIONABLE: Marco Farfan (undisclosed)
D.C. United
- OUT: Martin Rodriguez (knee)
- OUT: Mohanad Jeahze (ankle)
- OUT: Tyler Miller (shoulder)
Houston Dynamo FC
- OUT: Ifunanyachi Achara (knee)
- OUT: Tate Schmitt (knee)
- QUESTIONABLE: None
- OUT: Gaston Brugman (torn meniscus, left knee)
- OUT: Calegari (torn ACL, left knee)
- OUT: Javier "Chicharito" Hernandez (torn ACL, right knee)
- OUT: Martin Caceres (avulsion fracture, left knee)
- OUT: Jalen Neal (sports hernia surgery)
- OUT: Mark Delgado (head)
Inter Miami CF
- OUT: Ian Fray (ACL)
- OUT: Franco Negri (ACL)
- OUT: Corentin Jean (ACL)
- OUT: Sergii Kryvtsov (hamstring)
Minnesota United FC
- OUT: Ryen Jiba (knee)
- OUT: Robin Lod (knee)
- OUT: Robert Thorkelsson (adductor)
Nashville SC
- OUT: Nick DePuy (lower body)
- QUESTIONABLE: Randall Leal (lower body)
- OUT: Dylan Borrero (left knee season ending)
- OUT: Brandon Bye (right ACL season ending)
New York City FC
- OUT: Maxi Moralez (ACL)
New York Red Bulls
- OUT: Lewis Morgan (hip)
- OUT: Dante Vanzeir (back)
- OUT: Cory Burke (groin)
- OUT: Hassan Ndam (thigh)
- QUESTIONABLE: Daniel Edelman (upper body)
- QUESTIONABLE: Sean Nealis (groin)
- QUESTIONABLE: Omir Fernandez (ankle)
Orlando City SC
- OUT: Favian Loyola (left arm)
- OUT: Jack Lynn (left thigh)
Philadelphia Union
- OUT: Leon Flach (core)
- QUESTIONABLE: Jakob Glesnes (core)
Portland Timbers
- OUT: David Ayala (left knee)
- OUT: Jaroslaw Niezgoda (right knee)
- OUT: Eryk Williamson (right knee)
- OUT: Tega Ikoba (international duty)
Real Salt Lake
- OUT: Pablo Ruiz (knee)
- OUT: Bode Hidalgo (hamstring)
- PROBABLE: Erik Holt (shoulder)
- OUT: Nathan (ACL)
- OUT: JT Marcinkowski (knee)
Seattle Sounders FC
- OUT: Abdoulaye Cissoko (left quad strain)
Sporting Kansas City
- OUT: Kortne Ford (Achilles surgery)
- OUT: Logan Ndenbe (torn ACL)
- OUT: Kayden Pierre (hamstring)
- OUT: Felipe Gutierrez (knee)
- QUESTIONABLE: Dany Rosero (facial injury)
- OUT: Rasmus Alm (sports hernia)
Toronto FC
- OUT: Adama Diomande (lower body)
- OUT: Sigurd Rosted (lower body)
- OUT: Brandon Servania (lower body)
- QUESTIONABLE: Sean Johnson (hand surgery)
- QUESTIONABLE: Greg Ranjitsingh (knee surgery)
Vancouver Whitecaps FC
- OUT: Russell Teibert (hip joint irritation)
- OUT: Thomas Hasal (patellar tendinopathy)
