NOTE: This report is compiled on an ongoing basis by MLSsoccer.com editors based on club game notes, news reports, and original reporting. The league does not have an official player availability report.
- QUESTIONABLE: Matheus Rossetto (hamstring)
- OUT: Ozzie Alonso (ACL recovery)
- OUT: Luis Abram (international duty)
- OUT: Thiago Almada (international duty)
- OUT: Machop Chol (international duty)
- OUT: Derrick Etienne Jr. (international duty)
- OUT: Giorgos Giakoumakis (international duty)
- OUT: Ronald Hernández (international duty)
- OUT: Miles Robinson (international duty)
Austin FC
- OUT: Julio Cascante (left adductor)
- OUT: Josh Wolff (international duty)
- OUT: Leo Väisänen (international duty)
- OUT: Guzman Corujo (right knee surgery)
- OUT: Kristijan Kahlina (back surgery)
- OUT: Ashley Westwood (right thigh)
- OUT: Karol Swiderski (international duty)
- QUESTIONABLE: Bill Tuiloma (right thigh)
- OUT: Jairo Torres (right upper leg)
- OUT: Federico Navarro (left upper leg)
- OUT: Miguel Navarro (international duty)
- OUT: Sergio Oregel Jr. (international duty)
- OUT: Xherdan Shaqiri (right upper leg)
- OUT: Yuya Kubo (leg)
- OUT: Marco Angulo (international duty)
- OUT: Junior Moreno (international duty)
- QUESTIONABLE: Isaiah Foster (ankle)
Colorado Rapids
- OUT: Yaya Toure (right knee)
- OUT: Moise Bombito (left knee)
- OUT: Jack Price (Achilles)
- OUT: Diego Rubio (international duty)
- OUT: Darren Yapi (international duty)
- QUESTIONABLE: Alex Gersbach (left hamstring)
- QUESTIONABLE: Braian Galvan (groin)
- QUESTIONABLE: Steven Beitashour (right hamstring)
- OUT: Josh Williams (ankle)
- OUT: Luis Diaz (back)
- OUT: Cucho Hernandez (knee)
- OUT: Kevin Molino (knee)
- OUT: Milos Degenek (international duty)
- OUT: Eloy Room (international duty)
- OUT: Lucas Zelarayan (international duty)
FC Dallas
- OUT: Tarik Scott (season-ending injury)
- OUT: Antonio Carrera (international duty)
- OUT: Nolan Norris (international duty)
D.C. United
- OUT: Brendan Hines-Ike (foot)
- OUT: Martin Rodriguez (knee)
- OUT: Andy Najar (thigh)
- OUT: Pedro Santos (knee)
- OUT: Matai Akinmboni (head)
- OUT: Kristian Fletcher (international duty)
- OUT: Victor Pálsson (international duty)
- QUESTIONABLE: Taxi Fountas (thigh)
- QUESTIONABLE: Derrick Williams (thigh)
Houston Dynamo FC
- OUT: Brad Smith (left knee)
- OUT: Adalberto Carrasquilla (international duty)
- OUT: Juan Castilla (international duty)
- OUT: Xavier Valdez (international duty)
- QUESTIONABLE: Franco Escobar (lower body)
- OUT: Denis Bouanga (international duty)
- OUT: Jose Cifuentes (international duty)
- OUT: Denil Maldonado (international duty)
- OUT: Diego Palacios (international duty)
- OUT: Javier "Chicharito" Hernandez (hamstring)
- OUT: Douglas Costa (calf)
- OUT: Jonathan Bond (shoulder)
- OUT: Markus Ferkranus (international duty)
- OUT: Dejan Joveljic (international duty)
- OUT: Kelvin Leerdam (international duty)
- OUT: Eriq Zavaleta (international duty)
Inter Miami CF
- OUT: Noah Allen (knee)
- OUT: Ian Fray (knee)
- OUT: Gregore (Lisfranc)
- OUT: Edison Azcona (international duty)
- OUT: Josef Martínez (international duty)
- OUT: Robert Taylor (international duty)
- QUESTIONABLE: Leonardo Campana (calf)
- QUESTIONABLE: Robbie Robinson (calf)
- QUESTIONABLE: Shanyder Borgelin (ankle)
Minnesota United FC
- SUSPENDED: Emanuel Reynoso
- OUT: Bakaye Dibassy (thigh)
- OUT: Ryen Jiba (knee)
- OUT: Kervin Arriaga (international duty)
- OUT: Michael Boxall (international duty)
- OUT: Bongokuhle Hlongwane (international duty)
- OUT: Kemar Lawrence (international duty)
- OUT: Robin Lod (international duty)
- OUT: Joseph Rosales (international duty)
- OUT: Dayne St. Clair (international duty)
CF Montréal
- OUT: George Campbell (ankle)
- OUT: Matko Miljevic (knee)
- OUT: James Pantemis (shoulder)
- OUT: Jojea Kwizera (hamstring)
- OUT: Kamal Miller (calf)
- OUT: Romell Quioto (international duty)
- OUT: Robert Thorkelsson (international duty)
Nashville SC
- OUT: Nick DePuy (lower body)
- OUT: Randall Leal (lower body)
- QUESTIONABLE: Anibal Godoy (upper body)
- OUT: Nacho Gil (right leg)
- OUT: Tommy McNamara (left leg)
- OUT: Maciel (left Achilles)
- OUT: Jacob Jackson (left ACL)
- OUT: Christian Makoun (international duty)
- OUT: Dylan Borrero (international duty)
New York City FC
- OUT: Maxime Chanot (international duty)
- OUT: Mitja Ilenic (international duty)
New York Red Bulls
- OUT: Serge Ngoma (hamstring)
- OUT: Cory Burke (international duty)
- OUT: Cristian Casseres Jr. (international duty)
- OUT: Steve Sserwadda (international duty)
- QUESTIONABLE: Lewis Morgan (hip)
Orlando City SC
- OUT: Wilder Cartagena (international duty)
- OUT: Alexander Freeman (international duty)
- OUT: Michael Halliday (international duty)
- OUT: Pedro Gallese (international duty)
- OUT: Favian Loyola (international duty)
- OUT: Facundo Torres (international duty)
- OUT: Thomas Williams (international duty)
- QUESTIONABLE: Ercan Kara (right thigh)
Philadelphia Union
- OUT: Andre Blake (adductor strain)
- OUT: Brandon Craig (international duty)
- OUT: Daniel Gazdag (international duty)
- OUT: Damion Lowe (international duty)
- OUT: Jose Martinez (international duty)
- OUT: Jack McGlynn (international duty)
- OUT: Richard Odada (international duty)
- OUT: Quinn Sullivan (international duty)
Portland Timbers
- OUT: Felipe Mora (left knee)
- OUT: Sebastian Blanco (left knee)
- OUT: David Ayala (right knee)
- OUT: Dairon Asprilla (right knee)
- OUT: Yimmi Chara (right hamstring)
- OUT: Cristhian Paredes (right hamstring)
- OUT: Evander (hip)
- OUT: Juan David Mosquera (international duty)
Real Salt Lake
- OUT: Zach Farnsworth (thigh)
- OUT: Axel Kei (ankle)
- OUT: Bode Hidalgo (hamstring)
- OUT: Rubio Rubin (international duty)
- OUT: Braian Ojeda (international duty)
- OUT: Diego Luna (international duty)
- OUT: Gavin Beavers (international duty)
- QUESTIONABLE: Marcelo Silva (hamstring)
- QUESTIONABLE: Erik Holt (Achilles)
- QUESTIONABLE: Bryan Ovideo (calf)
- QUESTIONABLE: Jefferson Savarino (calf)
- QUESTIONABLE: Danny Musovski (ankle)
- QUESTIONABLE: Jasper Loffelsend (illness)
- OUT: Nathan (ACL surgery)
- OUT: Carlos Gruezo (hamstring)
- OUT: Niko Tsakiris (adductor)
- OUT: Daniel (thigh)
- OUT: Jamiro Monteiro (international duty)
- OUT: Miguel Trauco (international duty)
- QUESTIONABLE: Judson (knee)
Seattle Sounders FC
- OUT: Xavier Arreaga (international duty)
- OUT: Reed Baker-Whiting (international duty)
- OUT: Nouhou (international duty)
- OUT: Alex Roldan (international duty)
- OUT: Raul Ruidiaz (international duty)
- OUT: Obed Vargas (international duty)
- QUESTIONABLE: Heber (left hamstring strain)
Sporting Kansas City
- OUT: Kortne Ford (Achilles surgery)
- OUT: Logan Ndenbe (hamstring)
- OUT: Gadi Kinda (knee)
- OUT: Kayden Pierre (hamstring)
- OUT: Marinos Tzionis (international duty)
- QUESTIONABLE: Johnny Russell (hamstring)
- QUESTIONABLE: Alan Pulido (knee)
- QUESTIONABLE: Tim Leibold (hamstring)
- OUT: Joakim Nilsson (knee)
- OUT: Miguel Perez (international duty)
- OUT: Kyle Hiebert (international duty)
- QUESTIONABLE: Tim Parker (groin)
Toronto FC
- OUT: Cristian Gutierrez (illness)
- OUT: Adama Diomande (lower body)
- OUT: Lorenzo Insigne (lower body)
- OUT: Ayo Akinola (international duty)
- OUT: Mark-Anthony Kaye (international duty)
- OUT: Richie Laryea (international duty)
- OUT: Jonathan Osorio (international duty)
- OUT: Tomas Romero (international duty)
Vancouver Whitecaps FC
- OUT: Sergio Cordova (right hamstring strain)
- OUT: Javain Brown (international duty)
- OUT: Andres Cubas (international duty)
