NOTE: This report is compiled on an ongoing basis by MLSsoccer.com editors based on club game notes, news reports, and original reporting. The league does not have an official player availability report.
- None
Austin FC
- OUT: Leo Väisänen (foot)
- QUESTIONABLE: Sebastián Driussi (hamstring)
- OUT: Liel Abada (not due to injury)
- OUT: Ben Bender (left knee)
- OUT: Brandt Bronico (left thigh)
- OUT: Brandon Cambridge (right ankle)
- OUT: Tyger Smalls (bilateral lower leg)
- QUESTIONABLE: Enzo Copetti (thigh)
- OUT: Victor Bezerra (right upper leg)
- OUT: Andrew Gutman (upper leg)
- OUT: Federico Navarro (upper leg)
- OUT: Alec Kann (hand)
- OUT: Obinna Nwobodo (leg)
Colorado Rapids
- OUT: Daniel Chacón (knee)
- OUT: Connor Ronan (knee)
- QUESTIONABLE: Jasper Löffelsend (hamstring)
- OUT: Alex Matan (thigh)
FC Dallas
- OUT: Logan Farrington (knee)
- OUT: Asier Illarramendi (adductor)
- OUT: Geovane Jesus (right knee)
- OUT: Paxton Pomykal (knee)
- OUT: Alan Velasco (knee)
D.C. United
- OUT: Steven Birnbaum (knee)
- OUT: Tyler Miller (shoulder)
- OUT: Garrison Tubbs (thigh)
- QUESTIONABLE: Ted Ku-Dipietro (knee)
- QUESTIONABLE: Russell Canouse (ankle)
Houston Dynamo FC
- OUT: Hector Herrera (knee)
- OUT: Nelson Quinones (knee)
- QUESTIONABLE: Sebastian Ferreira (hamstring)
- QUESTIONABLE: Erik Sviatchenko (hamstring)
- OUT: Lorenzo Dellavalle (right knee)
- QUESTIONABLE: Tomás Ángel (adductor)
- OUT: Jalen Neal (abdominal)
Inter Miami CF
- OUT: Benjamin Cremaschi (sports hernia)
- OUT: Facundo Farias (knee)
- OUT: Ian Fray (knee)
- OUT: Lionel Messi (hamstring)
- OUT: Franco Negri (knee)
- OUT: Robbie Robinson (knee)
Minnesota United FC
- OUT: None
- OUT: Mahala Opoku (ankle)
- QUESTIONABLE: Jules-Anthony Vilsaint (knee)
Nashville SC
- OUT: Randall Leal (hip)
- OUT: Walker Zimmerman (knee)
- OUT: Brandon Bye (knee)
- OUT: Dylan Borrero (knee)
- OUT: Peyton Miller (foot)
- QUESTIONABLE: Carles Gil (Achilles)
- QUESTIONABLE: Nacho Gil (knee)
- QUESTIONABLE: Henry Kessler (adductor)
- QUESTIONABLE: Matt Polster (hamstring)
- QUESTIONABLE: Bobby Wood (knee)
New York City FC
- OUT: Rio Hope-Gund (abdomen)
- OUT: Maxi Moralez (right knee)
- OUT: Talles Magno (knee)
New York Red Bulls
- OUT: Serge Ngoma (hamstring)
- QUESTIONABLE: Ryan Meara (groin)
- QUESTIONABLE: Sean Nealis (adductor)
- QUESTIONABLE: Dante Vanzeir (hamstring)
Orlando City SC
- OUT: Wilder Cartagena (not due to injury)
- QUESTIONABLE: César Araújo (ankle)
- QUESTIONABLE: Jack Lynn (lower leg)
Philadelphia Union
- OUT: Leon Flach (left shoulder)
- OUT: Isaiah LeFlore (right knee)
- OUT: Holden Trent (finger)
Portland Timbers
- OUT: Claudio Bravo (left knee)
- OUT: Marvin Loria (left knee)
- OUT: Felipe Mora (right foot)
- QUESTIONABLE: Zac McGraw (knee)
Real Salt Lake
- OUT: Kevin Bonilla (left knee)
- OUT: Zack Farnsworth (shoulder)
- OUT: Pablo Ruiz (knee)
- QUESTIONABLE: Justen Glad (hamstring)
- OUT: Carlos Akapo (foot)
- OUT: JT Marcinkowski (knee surgery)
- OUT: Niko Tsakiris (lower body)
- OUT: Reed Baker-Whiting (left hamstring)
- OUT: Pedro de la Vega (hamstring)
- OUT: Stefan Frei (right hamstring)
- OUT: João Paulo (left hip)
- OUT: Braudilio Rodrigues (right hamstring)
- QUESTIONABLE: Nathan (not due to injury)
Sporting Kansas City
- OUT: Ozzie Cisneros (hamstring)
- OUT: Logan Ndenbe (knee)
- OUT: Khiry Shelton (ankle)
- QUESTIONABLE: Andreu Fontas (hamstring)
- QUESTIONABLE: Daniel Salloi (hip)
- QUESTIONABLE: Remi Walter (ankle)
- OUT: Eduard Löwen (hamstring)
- QUESTIONABLE: Njabulo Blom (knee)
- QUESTIONABLE: Josh Yaro (hamstring)
Toronto FC
- OUT: Nicksoen Gomis (wrist)
- OUT: Sean Johnson (thigh)
- OUT: Richie Laryea (thigh)
- OUT: Brandon Servania (knee)
- OUT: Jonathan Osorio (hip)
- QUESTIONABLE: Deybi Flores (groin)
- QUESTIONABLE: Kevin Long (foot)
- QUESTIONABLE: Raoul Petretta (groin)
Vancouver Whitecaps FC
- OUT: Sam Adekugbe (knee)