NOTE: This report is compiled on an ongoing basis by MLSsoccer.com editors based on club game notes, news reports, and original reporting. The league does not have an official player availability report.
- OUT: Jamal Thiaré (hamstring)
- OUT: Derrick Williams (calf)
- OUT: Xande Silva (adductor)
- QUESTIONABLE: Stian Gregersen (knee)
Austin FC
- QUESTIONABLE: Leo Väisänen (foot)
- QUESTIONABLE: Owen Wolff (ankle)
- OUT: Scott Arfield (back)
- OUT: Ben Bender (knee)
- OUT: Brandon Cambridge (ankle)
- OUT: Chase Gasper (upper leg)
- OUT: Maren Haile-Selassie (lower leg)
- QUESTIONABLE: Javier Casas (lower leg)
- QUESTIONABLE: Gastón Giménez (upper leg)
- QUESTIONABLE: Brian Gutiérrez (upper leg)
- QUESTIONABLE: Federico Navarro (upper leg)
- QUESTIONABLE: Xherdan Shaqiri (lower leg)
- OUT: Nick Hagglund (leg)
Colorado Rapids
- OUT: Daniel Chacón (knee)
- OUT: Jonathan Lewis (knee)
- OUT: Jasper Löffelsend (knee)
- OUT: Connor Ronan (knee)
- QUESTIONABLE: Lalas Abubakar (hamstring)
- QUESTIONABLE: Sam Vines (head)
- OUT: Evan Bush (arm)
FC Dallas
- OUT: Geovane Jesus (right knee)
- OUT: Sebastian Lletget (hamstring)
- OUT: Paxton Pomykal (knee)
- OUT: Alan Velasco (knee)
- QUESTIONABLE: Jesús Ferreira (hamstring)
D.C. United
- OUT: Conner Antley (leg)
- OUT: Russell Canouse (not due to injury)
- QUESTIONABLE: Steven Birnbaum (knee)
- QUESTIONABLE: Theodore Ku-Dipietro (hip)
- QUESTIONABLE: Garrison Tubbs (thigh)
Houston Dynamo FC
- OUT: Nelson Quiñónes (knee)
- QUESTIONABLE: Franco Escobar (lower body)
- QUESTIONABLE: Sebastian Ferreira (lower body)
- QUESTIONABLE: Héctor Herrera (knee)
- QUESTIONABLE: Erik Sviatchenko (hamstring)
- OUT: Lorenzo Dellavalle (right knee)
- OUT: David Martinez (back)
- QUESTIONABLE: Aaron Long (lower leg)
- OUT: Dejan Joveljic (thigh)
Inter Miami CF
- OUT: Jordi Alba (hamstring)
- OUT: Shanyder Borgelin (hamstring)
- OUT: Facundo FarÃas (knee)
- OUT: Ian Fray (knee)
- OUT: Sergii Kryvtsov (hamstring)
- OUT: Federico Redondo (knee)
- OUT: Robbie Robinson (knee)
Minnesota United FC
- OUT: Jordan Adebayo-Smith (ankle)
- OUT: Hugo Bacharach (knee)
- OUT: Emanuel Reynoso (not due to injury)
- QUESTIONABLE: Hassani Dotson (leg)
- OUT: Matias Coccaro (knee)
- OUT: Lassi Lappalainen (hip)
- OUT: Josef Martinez (knee)
- OUT: Mahala Opoku (ankle)
- OUT: Joaquin Sosa (lower leg)
Nashville SC
- OUT: Lukas MacNaughton (ankle)
- QUESTIONABLE: Tyler Boyd (hip)
- QUESTIONABLE: Randall Leal (hip)
- QUESTIONABLE: Shaq Moore (hip)
- QUESTIONABLE: Walker Zimmerman (knee)
- OUT: Brandon Bye (knee)
- OUT: DeJuan Jones (hamstring)
- OUT: Tommy McNamara (hamstring)
- OUT: Peyton Miller (foot)
- QUESTIONABLE: Dylan Borrero (knee)
- QUESTIONABLE: Noel Buck (quad)
- QUESTIONABLE: Malcolm Fry (calf)
- QUESTIONABLE: Jonathan Mensah (hamstring)
New York City FC
- OUT: Rio Hope-Gund (thigh)
- OUT: Talles Magno (knee)
- OUT: Maxi Moralez (right knee)
New York Red Bulls
- OUT: Ronald Donkor (hip)
- OUT: Roald Mitchell (knee)
- OUT: Serge Ngoma (knee)
- OUT: Peter Stroud (ankle)
- QUESTIONABLE: Frankie Amaya (ankle)
Orlando City SC
- OUT: Ramiro Enrique (ankle)
Philadelphia Union
- OUT: Markus Anderson (quad)
- OUT: Isaiah LeFlore (knee)
- OUT: Nick Pariano (knee)
- OUT: Holden Trent (hand)
- QUESTIONABLE: Andre Blake (leg)
- QUESTIONABLE: Damion Lowe (ankle)
Portland Timbers
- OUT: Marvin Loria (knee)
- QUESTIONABLE: Antony Alves Santos (lower leg)
- QUESTIONABLE: Evander (leg)
Real Salt Lake
- OUT: Kevin Bonilla (left knee)
- OUT: Erik Holt (hamstring)
- OUT: Diego Luna (calf)
- OUT: Pablo Ruiz (knee)
- OUT: Marcelo Silva (hamstring)
- QUESTIONABLE: Matt Crooks (oblique)
- QUESTIONABLE: Justen Glad (adductor)
- QUESTIONABLE: Brayan Vera (hip)
- OUT: Daniel Britto (lower body)
- OUT: JT Marcinkowski (knee)
- OUT: Bruno Wilson (lower body)
- QUESTIONABLE: Alfredo Morales (lower body)
- OUT: Pedro de la Vega (hamstring)
- OUT: Braudilio Rodrigues (right hamstring)
- QUESTIONABLE: Reed Baker-Whiting (left hamstring)
- QUESTIONABLE: Nathan (hip)
Sporting Kansas City
- OUT: Logan Ndenbe (knee)
- QUESTIONABLE: Stephen Afrifa (thigh)
- Matchday 11 bye
Toronto FC
- OUT: Lorenzo Insigne (thigh)
- OUT: Richie Laryea (thigh)
- OUT: Shane O’Neill (thigh)
- OUT: Brandon Servania (knee)
- QUESTIONABLE: Deandre Kerr (foot)
Vancouver Whitecaps FC
- QUESTIONABLE: Fafà Picault (back)
