NOTE: This injury report is compiled on an ongoing basis by MLSsoccer.com editors based on club game notes, news reports, and original reporting. Last Updated: November 8, 2020

Atlanta United FC
- OUT: F - Josef Martinez (torn ACL 2/29) - READ
- OUT: M - Mo Adams (not medically cleared)

Chicago Fire FC

FC Cincinnati
- OUT: M - Alvaro Barreal (not medically cleared)
- OUT: M - Allan Cruz (not medically cleared)

Colorado Rapids
- OUT: D - Kortne Ford (left knee injury)
- OUT: M - Collen Warner (not medically cleared)

Columbus Crew SC
- OUT: D - Vito Wormgoor (ankle injury)
- OUT: M - Fatai Alashe (not medically cleared)
- OUT: D - Hector Jimenez (not medically cleared)

FC Dallas
- OUT: M - Paxton Pomykal (labrum surgery 9/3, out 6 months) - READ
- OUT: M - Bryan Acosta (not medically cleared)

D.C. United
- OUT: M - Felipe (ACL surgery 9/4, out for season) - READ
- OUT: M - Mohammed Abu (knee injury) - REPORT
- OUT: M - Ulises Segura (not medically cleared) - REPORT
- OUT: D - Steve Birnbaum (not medically cleared)
- QUESTIONABLE: D - Chris Odoi-Atsem (undisclosed injury)
- QUESTIONABLE: D - Joseph Mora (undisclosed injury)

Houston Dynamo FC
- OUT: F - Michael Salazar (right knee injury)

LAFC
- OUT: D - Andy Najar (not medically cleared)
- OUT: D - Mohamed El-Munir (not medically cleared)
- OUT: F - Adrien Perez (not medically cleared)
- OUT: F - Danny Musovski (not medically cleared)

LA Galaxy
- QUESTIONABLE: D - Danilo Acosta (ACL surgery 2/21, out 7-9 months) - READ
- QUESTIONABLE: M - Jonathan dos Santos (left calf strain)

Inter Miami CF
- OUT: M - George Acosta (left knee injury)
- OUT: M - David Norman Jr. (left ankle injury)
- OUT: D - Denso Ulysse (left lower leg injury)
- OUT: GK - Luis Robles (left arm fracture)
- OUT: D - Nicolas Figal (not medically cleared)

Minnesota United
- OUT: GK - Tyler Miller (hip surgery 8/19, out for season) - READ
- OUT: D - Ike Opara (not medically cleared)
- OUT: F - Luis Amarilla (ankle injury 9/8, out for season)
- OUT: M - Hassani Dotson (ankle injury) - REPORT
- OUT: M - Osvaldo Alonso (not medically cleared)
- OUT: M - Jacori Hayes (not medically cleared)

CF Montréal
- OUT: M - Lassi Lappalainen (shoulder surgery 10/21, out for season) - READ
- OUT: M - Matheiu Choiniere (ankle injury)

Nashville SC
- OUT: F - Dominique Badji (not medically cleared)
- OUT: F - Abu Danladi (not medically cleared)
- OUT: D - Jack Maher (not medically cleared)

New England Revolution

New York City FC

New York Red Bulls
- OUT: D - Patrick Seagrist (groin injury)

Orlando City SC
- OUT: F - Dom Dwyer (knee injury) - READ
- OUT: D - Joao Moutinho (groin injury)
- OUT: D - Michael Halliday (not medically cleared)
- OUT: M - David Loera (not medically cleared)

Philadelphia Union
- OUT: GK - Andre Blake (not medically cleared)
- OUT: D - Matt Real (not medically cleared)

Portland Timbers
- OUT: M - Sebastian Blanco (torn ACL 9/6, out for season) - READ
- OUT: D - Julio Cascante (left ankle injury)
- OUT: F - Jaroslaw Niezgoda (torn ACL, out for season) - READ
- QUESTIONABLE: M - Dairon Asprilla (left knee surgery 5/21)
- QUESTIONABLE: F - Blake Bodily (right thigh injury)
- QUESTIONABLE: F - Jeremy Ebobisse (concussion)

Real Salt Lake
- OUT: F - Giuseppe Rossi (not medically cleared)
- OUT: M - Chris Garcia (not medically cleared)

San Jose Earthquakes
- OUT: F - Danny Hoesen (thigh injury)
- QUESTIONABLE: M - Carlos Fierro (thigh injury)

Seattle Sounders
- OUT: D - Shane O'Neill (concussion protocol)
- QUESTIONABLE: D - Brad Smith (right adductor strain)
- QUESTIONABLE: M - Gustav Svensson (right hip contusion)

Sporting Kansas City
- OUT: M - Felipe Gutierrez (knee injury 6/9, out for season)
- OUT: D - Graham Zusi (foot surgery 10/21, out for season) - READ
- OUT: M - Gadi Kinda (not medically cleared)
- OUT: F - Wilson Harris (not medically cleared)
- OUT: F - Alan Pulido (not medically cleared)

Toronto FC
- OUT: M - Achara (ACL surgery 7/9, out for season)
- OUT: GK - Alex Bono (not medically cleared)
- OUT: M - Pablo Piatti (not medically cleared)
- OUT: D - Justin Morrow (not medically cleared)
- OUT: M - Marky Delgado (undisclosed injury)

Vancouver Whitecaps
- OUT: GK - Maxime Crepeau (fractured left thumb, surgery 7/27)
- OUT: GK - Thomas Hasal (left tibia stress fracture, concussion 9/28) - REPORT