September 2010
| Sat Sep 04, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 3:30pm ET | Philadelphia | Kansas City | PPL Park | ||||
| 4:00pm ET | Chicago | Los Angeles | Telefutura | Toyota Park | |||
| 7:30pm ET | D.C. United | Columbus | FSC/FSE | RFK Stadium | |||
| 7:30pm ET | New England | Preview | Seattle | Gillette Stadium | |||
| 8:30pm ET | FC Dallas | Preview | Toronto FC | Pizza Hut Park | |||
| 9:00pm ET | Colorado | Chivas USA | Dick's Sporting Goods Park | ||||
| 9:00pm ET | Real Salt Lake | New York | Rio Tinto Stadium | ||||
| Sun Sep 05, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 8:30pm ET | Houston | San Jose | Robertson Stadium | ||||
| Wed Sep 08, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 8:30pm ET | Chicago | Toronto FC | Toyota Park | ||||
| Thu Sep 09, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 11:00pm ET | Seattle | Real Salt Lake | ESPN2/Deportes | Qwest Field | |||
| Fri Sep 10, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 10:30pm ET | Chivas USA | New England | The Home Depot Center | ||||
| Sat Sep 11, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 4:00pm ET | Toronto FC | D.C. United | BMO Field | ||||
| 4:00pm ET | New York | Colorado | Telefutura | Red Bull Arena | |||
| 6:00pm ET | Philadelphia | Chicago | FSC/FSE | PPL Park | |||
| 10:00pm ET | San Jose | FC Dallas | Buck Shaw Stadium | ||||
| 10:30pm ET | Los Angeles | Columbus | The Home Depot Center | ||||
| Wed Sep 15, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 10:00pm ET | San Jose | Philadelphia | Buck Shaw Stadium | ||||
| Thu Sep 16, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 9:00pm ET | FC Dallas | New York | Pizza Hut Park | ||||
| Sat Sep 18, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 9:00am ET | Colorado | New England | Dick's Sporting Goods Park | ||||
| 4:00pm ET | Real Salt Lake | Chicago | Telefutura | Rio Tinto Stadium | |||
| 7:30pm ET | Columbus | Seattle | Columbus Crew Stadium | ||||
| 8:30pm ET | Houston | Toronto FC | Robertson Stadium | ||||
| 10:30pm ET | Los Angeles | D.C. United | FSC/FSE | The Home Depot Center | |||
| Sun Sep 19, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 8:00pm ET | Chivas USA | Kansas City | The Home Depot Center | ||||
| Wed Sep 22, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 8:30pm ET | FC Dallas | New England | Pizza Hut Park | ||||
| 8:30pm ET | Kansas City | Houston | CommunityAmerica Ballpark | ||||
| Fri Sep 24, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 11:00pm ET | Los Angeles | New York | ESPN2/Deportes | The Home Depot Center | |||
| Sat Sep 25, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 4:00pm ET | Philadelphia | Chivas USA | Telefutura | PPL Park | |||
| 4:00pm ET | Toronto FC | San Jose | BMO Field | ||||
| 7:30pm ET | D.C. United | Houston | RFK Stadium | ||||
| 7:30pm ET | New England | Columbus | Gillette Stadium | ||||
| 8:00pm ET | Chicago | Seattle | Toyota Park | ||||
| 8:00pm ET | Kansas City | FC Dallas | CommunityAmerica Ballpark | ||||
| 10:00pm ET | Real Salt Lake | Colorado | FSC/FSE | Rio Tinto Stadium | |||
| Wed Sep 29, 2010 | |||||||
| Home | Away | Venue (tickets) | |||||
| 9:30pm ET | Colorado | Philadelphia | Dick's Sporting Goods Park | ||||
| 11:00pm ET | San Jose | Chicago | ESPN2/Deportes | Buck Shaw Stadium | |||
