They are the two players who will more than likely prove the difference makers in the Cascadia Cup match-up at CenturyLink Field on Sunday (10 pm ET, ESPN2).
Designated Players Diego Valeri (Portland Timbers) and Clint Dempsey (Seattle Sounders) will be marked men as the attacking centerpieces of their respective teams and both will be expected to produce on the big national TV stage.
Clint Dempsey is set to make his MLS debut on Saturday in Toronto. But should he be departing Canada and heading straight to Sarajevo for the US national team's friendly against Bosnia-Herzegovina on Aug. 14?
On Friday, word came across the pond that longtime US national team No. 1 Tim Howard has a pair of broken bones in his back, likely ruling him out of a pair of World Cup qualifiers later this month. The first is March 22 in Denver against Costa Rica, with the second four days later down in Mexico City.
In the opening weekend of MLS action, a couple of Argentine forwards stole the headlines. Federico Higuain sparked the Columbus Crew's 3-0 win over Chivas USA with a stunning long-ranger, and newcomer Diego Valeri led the Portland Timbers to a thrilling comeback draw with New York.
On Monday, the Chicago Fire sent forward Dominic Oduro to the Columbus Crew for midfielder Dilly Duka and the right of first refusal on the possible future signing of midfielder Robbie Rogers.
That, of course, got us chatting and sparked another example of what we like to call internally: The Big Debate. (It's better when you say it with a deep, James Earl Jones-type voice.)